Endometriosis and menopausal hormone therapy impact the hysterectomy-ovarian cancer association

L Khoja; RP Weber; PM Webb; SJ Jordan; A Muthukumar; J Chang-Claude; RT Fortner; A Jensen; SK Kjaer; H Risch; JA Doherty; HR Harris; MT Goodman; F Modugno; K Moysich; A Berchuck; JM Schildkraut; D Cramer; KL Terry; H Anton-Culver; A Ziogas; MT Phung; GE Hanley; AH Wu; B Mukherjee; K McLean; K Cho; MC Pike; CL Pearce; AW Lee

Journal article

Endometriosis and menopausal hormone therapy impact the hysterectomy-ovarian cancer association

L Khoja, RP Weber, PM Webb, SJ Jordan, A Muthukumar, J Chang-Claude, RT Fortner, A Jensen, SK Kjaer, H Risch, JA Doherty, HR Harris, MT Goodman, F Modugno, K Moysich, A Berchuck, JM Schildkraut, D Cramer, KL Terry, H Anton-Culver Show all

Gynecologic Oncology | Published : 2022

DOI: 10.1016/j.ygyno.2021.10.088

Abstract

Objective: To evaluate the association between hysterectomy and ovarian cancer, and to understand how hormone therapy (HT) use and endometriosis affect this association. Methods: We conducted a pooled analysis of self-reported data from 11 case-control studies in the Ovarian Cancer Association Consortium (OCAC). Women with (n = 5350) and without ovarian cancer (n = 7544) who never used HT or exclusively used either estrogen-only therapy (ET) or estrogen+progestin therapy (EPT) were included. Risk of invasive epithelial ovarian cancer adjusted for duration of ET and EPT use and stratified on history of endometriosis was determined using odds ratios (ORs) with 95% confidence intervals (CIs). R..

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